|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, let-7c overexpression reversed the promotional effect of HoxB7 on tumor growth in subcutaneous HCC tumor model.
|
31609764 |
2020 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the let-7c/HoxB7 axis regulates HCC development, which may provide a novel therapeutic strategy for the treatment of HCC.
|
31609764 |
2020 |
|
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to investigate the relationship between HoxB7 and let-7c in liver carcinogenesis.
|
31609764 |
2020 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOXB7 is one member of HOX family genes, which are essential developmental regulators and frequently dysregulated in cancer.
|
31568655 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Conclusion:</b> HOXB7 accelerated the malignancy of GC, by facilitating EMT and regulating the Scr-FAK pathway.
|
31190875 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Deregulated HOXB7 expression predicts poor prognosis of patients with malignancies of digestive system.
|
28749115 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HOXB7 protein expression level in tumor tissue might serve as a novel prognostic marker for digestive system cancers.
|
28749115 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The association between HOXB7 expression detected by immunohistochemisty and tumor regression grade (TRG) and long-term survival was analyzed in 143 ESCC patients who underwent neoadjuvant chemotherapy.
|
31568655 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
QRT-PCR results showed that the level of HOXB7 in glioma tumor tissue specimens was conspicuously higher than that in the adjacent normal ones.
|
30964174 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A xenograft tumor model was established in nude mice to assess the role of HOXB7 in tumor growth and lung metastasis.
|
30664713 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
On the contrary, HOXB7 overexpression showed a tumor-promoting effect on human GC cells.
|
31190875 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
<b>Results:</b> Knockdown of HOXB7 suppressed cell proliferation, alleviated the wound-healing process, inhibited cell migration and invasion, and arrested the cell cycle while promoting cell apoptosis, suggesting the tumor-suppressive effect of siHOXB7 in human GC cells.
|
31190875 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
It showed that altered expression of HOXB7 protein was correlated with tumor invasion (P=0.000), lymph node status (P=0.000), distant metastasis (P=0.001) and TNM stage (P=0.000).
|
28749115 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of HoxB7 showed a suppressive effect on proliferation, migration, and invasion in the HTR-8/SVneo cells.
|
31103063 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
It showed that altered expression of HOXB7 protein was correlated with tumor invasion (P=0.000), lymph node status (P=0.000), distant metastasis (P=0.001) and TNM stage (P=0.000).
|
28749115 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Our results demonstrate the prognostic value of HOXB7 and its role in metastasis and angiogenesis in ICC.
|
30664713 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The occurrence of lymph node or distant metastasis was higher and the prognosis was worse in patients with higher HOXB7 expression.
|
30964174 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
HOXB7 is one member of HOX family genes, which are essential developmental regulators and frequently dysregulated in cancer.
|
31568655 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
<b>Conclusion:</b> HOXB7 accelerated the malignancy of GC, by facilitating EMT and regulating the Scr-FAK pathway.
|
31190875 |
2019 |
|
Colorectal Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We further demonstrated that circIFT80/miR-1236-3p/HOXB7 axis plays an important role in regulating CRC progression.
|
31648103 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
A xenograft tumor model was established in nude mice to assess the role of HOXB7 in tumor growth and lung metastasis.
|
30664713 |
2019 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
<b>Aim:</b> To study the carcinogenetic mechanism of HOXB7 in gastric cancer (GC) remains.
|
31190875 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The association between HOXB7 expression detected by immunohistochemisty and tumor regression grade (TRG) and long-term survival was analyzed in 143 ESCC patients who underwent neoadjuvant chemotherapy.
|
31568655 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.030 |
Biomarker
|
disease |
BEFREE |
Previously, HOXB7, HOXC6 and HOXC8 were found abnormally upregulated in esophageal squamous cell carcinoma (ESCC) tissues compared with normal mucosa and seen as poor prognostic predictors for ESCC patients, and were shown to promote cell proliferation and anti-apoptosis in ESCC cells.
|
30844117 |
2019 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
<b>Aim:</b> To study the carcinogenetic mechanism of HOXB7 in gastric cancer (GC) remains.
|
31190875 |
2019 |